Lecture Offerings

Lectures and comprehensive digital handouts are available for each of the following radiation and cancer biology topics:

  • Introduction and Overview - Free sample download (.pdf)
  • Radiation Chemistry
  • DNA Damage and Repair
  • Genetic, Mutagenic, Cytogenetic and Epigenetic Effects of Radiation
  • Modes of Cell Death
  • In Vitro and In Vivo Survival Curves
  • Sublethal and Potentially Lethal Damage Recovery
  • RBE and LET Effects, High LET Radiotherapy
  • Radiation-Induced Effects on the Mammalian Cell Cycle
  • Transformation, Carcinogenesis and Risk Assessment
  • The Tumor Microenvironment 1: Oxygen Effect and Hypoxia
  • The Tumor Microenvironment 2: Tumor Angiogenesis and Metastasis
  • The Tumor Microenvironment 3: Immunology and Immunotherapy
  • Radiosensitizers, Radioprotectors and Bioreductive Drugs
  • Normal and Tumor Cell Kinetics
  • "Early" and "Late" Effects in Normal Tissues
  • Radiation Histopathology/Cytokines/Volume Effects/Retreatment Tolerance
  • The 4 R's of Radiotherapy
  • Dose Rate and Dose Fractionation Effects
  • History of Modern Dose-Time Relationships
  • The Alpha-Beta Isoeffect Model
  • Experimental Chemotherapy: Drug Resistance
  • Emerging Science (Gene Therapy, Cancer Nanotechnology, Stem Cells)

The entire lecture series (approximately 40 lecture hours) has been developed with the educational needs of the radiation oncology resident in mind.  The first half of the lecture series only would be more appropriate for medical imaging residents (approximately 20 lecture hours).  

An approximately 20 lecture-hour course suitable for fulfillment of the ABR radiobiology requirement for therapeutic medical physics is also offered.

Less rigorous lecture offerings are available for radiographers and radiologic technologists (10-15 lecture hours) and radiation therapists (25-30 lecture hours). 

© Elaine M. Zeman, Ph.D. • 1999 - 2017